Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system

C Flores - Journal of Psychiatry and Neuroscience, 2011 - jpn.ca
Changes in mesocorticolimbic dopamine (DA) neurons and their target cells can be induced
throughout life and are important determinants of individual differences in susceptibility to …

Netrin‐1 receptor‐deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine

A Grant, D Hoops, C Labelle‐Dumais… - European Journal of …, 2007 - Wiley Online Library
The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental
psychiatric disorders including schizophrenia but it is unknown how disruptions in brain …

Post‐pubertal emergence of a dopamine phenotype in netrin‐1 receptor‐deficient mice

A Grant, Z Speed, C Labelle‐Dumais… - European Journal of …, 2009 - Wiley Online Library
During the pubertal period the mesocortical dopamine (DA) system undergoes substantial
reorganization of neuronal connectivity and functional refinement. Netrins are guidance …

The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence

DE Vosberg, M Leyton, C Flores - Molecular psychiatry, 2020 - nature.com
Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Regulation of netrin-1 receptors by amphetamine in the adult brain

L Yetnikoff, C Labelle-Dumais, C Flores - Neuroscience, 2007 - Elsevier
Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal
connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer …

Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period

L Yetnikoff, A Almey, A Arvanitogiannis, C Flores - Psychopharmacology, 2011 - Springer
Rationale Netrin-1 guidance cues contribute to amphetamine-induced plasticity of the adult
mesocorticolimbic dopamine system in rodents. The netrin-1 receptor, deleted in colorectal …

Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine

C Flores, C Manitt, D Rodaros, KM Thompson… - Molecular …, 2005 - nature.com
Netrins are guidance cues that play a fundamental role in organizing the developing brain.
The netrin receptor, DCC (deleted in colorectal cancer), is highly expressed by …

[HTML][HTML] Dopamine axon targeting in the nucleus accumbens in adolescence requires netrin-1

S Cuesta, D Nouel, LM Reynolds… - Frontiers in Cell and …, 2020 - frontiersin.org
The fine arrangement of neuronal connectivity during development involves the coordinated
action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still …

Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine

M Pokinko, L Moquin, A Torres-Berrío, A Gratton… - …, 2015 - Springer
Rationale Signaling through the netrin-1 receptor, deleted in colorectal cancer (DCC), in
dopamine neurons controls the extent of their innervation to the medial prefrontal cortex …

The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry

C Manitt, A Mimee, C Eng, M Pokinko… - Journal of …, 2011 - Soc Neuroscience
Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …