Objective: To determine the effectiveness of lithium prophylaxis in unipolar major depressive
disorder (MDD) and to identify predictors of outcome including comedication. Methods: In …

Meta-analysis was used to establish the efficacy of lithium in acute treatment and
prophylaxis of depressive illness from existing published clinical trials. Effect sizes were …

The authors assessed results obtained with long-term lithium maintenance in a group of 33
recurrent unipolar patients, followed regularly in the outpatient clinic of the Chaim Sheba …

In the 1970s, several randomized controlled trials demonstrated significant antimanic and
antidepressant properties of lithium in the prophylactic treatment of bipolar disorder …

This review is based an relevant publications and addresses the following questions: Does
lithium exert a recurrence-preventive, prophylactic action in manic-depressive ill-ness? Has …

Background Depressive disorders are a leading cause of the global burden of disease and
are associated with high recurrent often continuing morbidity and high excess mortality by …

Forty unipolar patients satisfying DSM–III criteria for major depression who discontinued
lithium therapy were retrospectively compared with 105 similar patients who continued the …

Recent high-quality studies have confirmed the central role of lithium in the treatment of
bipolar disorder and have established lithium as the drug of first choice for long-term …

Lithium is one of the most studied agents used to augment the pharmacologic effect of
antidepressant drugs, particularly in refractory depression. We reviewed 22 case reports, 22 …

Affective disorders are a major cause of morbidity and disability among middle‐aged and
older people. Thus, the prophylaxis of both unipolar depression and bipolar disorder in this …