Background: Results of neuroimaging and postmortem studies suggest that people with
schizophrenia may have lower levels of muscarinic M1 receptors (CHRM1) in the cortex, but …

Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors
(CHRM1) in patients with schizophrenia which is significant because CHRM signalling has …

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in
schizophrenia (Sz), with one study showing Sz can be separated into two populations based …

Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined
number of diseases probably with differing pathologies. Although studying a syndrome …

Multiple lines of evidence argue for lower levels of cortical muscarinic M1 receptors
(CHRM1) in people with schizophrenia which is possibly due to a sub-group within the …

To test the hypothesis that muscarinic receptors are involved in the pathology of
schizophrenia, we measured muscarinic 1 (M1R) and muscarinic 4 (M4R) protein and …

Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated
in the pathology of schizophrenia. Here we have assessed whether the receptor function of …

OBJECTIVE: Aberrant cholinergic inputs and synaptic neurotransmission in the prefrontal
cortex induce cognitive impairment, which is a central feature of schizophrenia. Postsynaptic …

Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …

We previously identified a group of subjects with schizophrenia who, on average, have a
75% decrease in cholinergic receptor, muscarinic 1 (CHRM1) in Brodmann's area (BA) 9. To …