Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task
Background: The dopamine (DA) D 2 receptors exist in 2 states: a high-affinity state (D 2
high) that is linked to second messenger systems, responsible for functional effects, exhibits …
high) that is linked to second messenger systems, responsible for functional effects, exhibits …
[HTML][HTML] The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study
The dopamine D 2 receptors exist in two states: a high-affinity state (D 2 high) that is linked
to second messenger systems, is responsible for functional effects, and exhibits high affinity …
to second messenger systems, is responsible for functional effects, and exhibits high affinity …
Affinity states of striatal dopamine D2 receptors in antipsychotic-free patients with schizophrenia
M Kubota, T Nagashima, H Takano… - International Journal …, 2017 - academic.oup.com
Background Dopamine D2 receptors are reported to have high-affinity (D2High) and low-
affinity (D2Low) states. Although an increased proportion of D2High has been demonstrated …
affinity (D2Low) states. Although an increased proportion of D2High has been demonstrated …
Recent evidence for dopamine abnormalities in schizophrenia
A Abi-Dargham - European Psychiatry, 2002 - cambridge.org
Neuroreceptor imaging has been used to examine dopamine function in schizophrenia. The
evidence from PET and SPECT studies suggests that there is excess dopamine release …
evidence from PET and SPECT studies suggests that there is excess dopamine release …
[HTML][HTML] Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
P Plavén-Sigray, P Ikonen Victorsson, A Santillo… - Molecular …, 2022 - nature.com
Pharmacological and genetic evidence support a role for an involvement of the dopamine
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
Extrastriatal dopamine D2/3 receptor density and distribution in drug-naive schizophrenic patients
H Tuppurainen, J Kuikka, H Viinamäki… - Molecular …, 2003 - nature.com
Several lines of studies have suggested the importance of cortical dopamine (DA)
transmission in the pathophysiology of schizophrenia. The putative alteration of striatal D 2 …
transmission in the pathophysiology of schizophrenia. The putative alteration of striatal D 2 …
Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients
Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D2
receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the …
receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the …
Dopamine agonist radioligand binds to both D2High and D2Low receptors, explaining why alterations in D2High are not detected in human brain scans
P Seeman - Synapse, 2012 - Wiley Online Library
The features of schizophrenia are consistent with increased sensitivity to endogenous
dopamine. Animal models of schizophrenia reveal an increase in the in vitro proportion of …
dopamine. Animal models of schizophrenia reveal an increase in the in vitro proportion of …
Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition
EH Simpson, V Winiger, DK Biezonski, I Haq… - Biological …, 2014 - Elsevier
Background Evidence indicating an increase in dopamine D2 receptor (D2R) density and
occupancy in patients with schizophrenia comes from positron emission tomography studies …
occupancy in patients with schizophrenia comes from positron emission tomography studies …
PET Study of D1 Dopamine Receptor Binding in Neuroleptic-Naive Patients With Schizophrenia
P Karlsson, L Farde, C Halldin… - American Journal of …, 2002 - Am Psychiatric Assoc
OBJECTIVE: Postmortem studies and a positron emission tomography (PET) study have
suggested that there is a disturbance of central D1 dopamine receptor function in …
suggested that there is a disturbance of central D1 dopamine receptor function in …