Background: Smaller hippocampal volumes in major depressive disorder (MDD) have been
linked with earlier onset, previous recurrences and treatment refractoriness. The aim of our …

The neural underpinnings of major depressive disorder (MDD) are unknown but there is
evidence for structural alteration in the hippocampus that may become more pronounced …

Recent evidence suggests that Alzheimer's disease (AD) and depression share common
mechanisms of pathogenesis. In particular, deregulation of glutamate-mediated excitatory …

Furthermore, expression of the glial excitatory amino acid transporters, responsible for glial
glutamate reuptake, was found to be reduced in individuals with major depression …

Hippocampal volume reduction has been related to treatment-resistant depression (TRD)
and is hypothesized to reflect impaired amino-acid neurotransmission. To better understand …

Background: Functional imaging studies suggest a specific role of the anterior brain regions
in the pathogenesis of major depression. The aim of this study was to evaluate possible …

Background Smaller hippocampal volumes, as assessed by magnetic resonance imaging
(MRI), and proton magnetic resonance spectroscopy (1 H-MRS) indexed alterations in brain …

BackgroundEvidence for structural hippocampal change in depression is limited despite
reports of neuronal damage due to hypercortisolaemia and vascular pathology. AimsTo …

Inflammation and altered glutamate metabolism are two pathways implicated in the
pathophysiology of depression. Interestingly, these pathways may be linked given that …

Major depressive disorder (MDD), common in the elderly, is a risk factor for dementia.
Abnormalities in glutamatergic neurotransmission via the N-methyl-d-aspartate receptor …