Background: The present study examined whether mitochondrial DNA copy number
(mtDNAcn) and telomere length—key markers of cellular aging—were altered in male and …

Abstract The 10–15-years decrease in life expectancy observed in individuals with bipolar
disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length …

Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …

Background Telomere shortening and alterations of mitochondrial biogenesis are involved
in cellular aging. Childhood adversity is associated with telomere shortening, and several …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Gender differences in the lifetime prevalence of post-traumatic stress disorder (PTSD) have
been well described with rates reported as approximately 10%–12% in females and 5%–6 …

DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably
change with age and can be used to derive “epigenetic age”, an indicator of biological age …

Mitochondrial dysfunction may play a role in various psychiatric conditions. Mitochondrial
DNA copy number (mtDNAcn), the ratio of mitochondrial DNA to nuclear DNA, represents an …

Objective Several studies have found associations between a diagnosis or symptoms of
major depressive disorder and markers of cellular aging and dysfunction. These …

Mitochondrial dysfunction is implicated in the pathophysiology of major depressive disorder
(MDD). This dysfunction can be indirectly assessed using the mitochondrial DNA (mtDNA) …