Background Late-life depression is often associated with non-response or relapse following
conventional antidepressant treatment. The pathophysiology of late-life depression likely …

Executive dysfunction is a common and disabling component of late-life depression (LLD),
yet its neural mechanisms remain unclear. In particular, it is not yet known how executive …

Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Objective: To characterize the functional neuroanatomy of late-life depression (LLD) by
probing for both episodic and persistent alterations in the executive-control circuit of elderly …

Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Recent studies suggest that neuropsychological measures involving the prefrontal cortex
are associated with treatment remission in late-life depression. To further explore this issue …

Objective This study investigated neural substrate changes in affective processing among
late-life depression (LLD) patients undergoing antidepressant treatment and determined if …

Pharmacological treatment of major depressive disorder (MDD) typically involves a lengthy
trial and error process to identify an effective intervention. This lengthy period prolongs …

Major depression in older adults, or late‐life depression (LLD), is a common and debilitating
psychiatric disorder that increases the risk of morbidity and mortality. Although the effects of …

Background Older adults with late-life depression (LLD) often experience incomplete or lack
of response to first-line pharmacotherapy. The treatment of LLD could be improved using …