Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review

J Soler, L Fañanás, M Parellada, MO Krebs… - Journal of Psychiatry and …, 2018 - jpn.ca
Scaffolding proteins represent an evolutionary solution to controlling the specificity of
information transfer in intracellular networks. They are highly concentrated in complexes …

Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders

JT Ting, J Peca, G Feng - Annual review of neuroscience, 2012 - annualreviews.org
Functional studies on postsynaptic scaffolding proteins at excitatory synapses have revealed
a plethora of important roles for synaptic structure and function. In addition, a convergence of …

[HTML][HTML] Identification and functional characterization of rare SHANK2 variants in schizophrenia

S Peykov, S Berkel, M Schoen, K Weiss… - Molecular …, 2015 - nature.com
Recent genetic data on schizophrenia (SCZ) have suggested that proteins of the
postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three …

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

EM Kenny, P Cormican, S Furlong, E Heron… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex
neurodevelopmental disorders that may share an underlying pathology suggested by …

Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral …

A de Bartolomeis, G Latte, C Tomasetti… - Molecular neurobiology, 2014 - Springer
Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …

[HTML][HTML] Population-Specific Haplotype Association of the Postsynaptic Density Gene DLG4 with Schizophrenia, in Family-Based Association Studies

S Balan, K Yamada, E Hattori, Y Iwayama, T Toyota… - PloS one, 2013 - journals.plos.org
The post-synaptic density (PSD) of glutamatergic synapses harbors a multitude of proteins
critical for maintaining synaptic dynamics. Alteration of protein expression levels in this …

[HTML][HTML] Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients

A Schmitt, F Leonardi-Essmann… - European archives of …, 2012 - Springer
Inaccurate wiring and synaptic pathology appear to be major hallmarks of schizophrenia. A
variety of gene products involved in synaptic neurotransmission and receptor signaling are …

Scaffold proteins at the postsynaptic density

C Verpelli, MJ Schmeisser, C Sala… - … development and disease, 2012 - Springer
Scaffold proteins are abundant and essential components of the postsynaptic density (PSD).
They play a major role in many synaptic functions including the trafficking, anchoring, and …

Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity

X Liu, Z Li, C Fan, D Zhang, J Chen - Journal of medical genetics, 2017 - jmg.bmj.com
The diagnosis of debilitating psychiatric disorders like autism spectrum disorder (ASD) and
schizophrenia (SCHZ) is on the rise. These are severe conditions that lead to social isolation …

The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis

A Hargreaves, R Anney, C O'Dushlaine… - Psychological …, 2014 - cambridge.org
BackgroundGenetic studies of single gene variants have been criticized as providing a
simplistic characterization of the genetic basis of illness risk that ignores the effects of other …