Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review
J Soler, L Fañanás, M Parellada, MO Krebs… - Journal of Psychiatry and …, 2018 - jpn.ca
Scaffolding proteins represent an evolutionary solution to controlling the specificity of
information transfer in intracellular networks. They are highly concentrated in complexes …
information transfer in intracellular networks. They are highly concentrated in complexes …
Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders
Functional studies on postsynaptic scaffolding proteins at excitatory synapses have revealed
a plethora of important roles for synaptic structure and function. In addition, a convergence of …
a plethora of important roles for synaptic structure and function. In addition, a convergence of …
[HTML][HTML] Identification and functional characterization of rare SHANK2 variants in schizophrenia
S Peykov, S Berkel, M Schoen, K Weiss… - Molecular …, 2015 - nature.com
Recent genetic data on schizophrenia (SCZ) have suggested that proteins of the
postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three …
postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three …
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders
Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex
neurodevelopmental disorders that may share an underlying pathology suggested by …
neurodevelopmental disorders that may share an underlying pathology suggested by …
Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral …
A de Bartolomeis, G Latte, C Tomasetti… - Molecular neurobiology, 2014 - Springer
Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …
[HTML][HTML] Population-Specific Haplotype Association of the Postsynaptic Density Gene DLG4 with Schizophrenia, in Family-Based Association Studies
S Balan, K Yamada, E Hattori, Y Iwayama, T Toyota… - PloS one, 2013 - journals.plos.org
The post-synaptic density (PSD) of glutamatergic synapses harbors a multitude of proteins
critical for maintaining synaptic dynamics. Alteration of protein expression levels in this …
critical for maintaining synaptic dynamics. Alteration of protein expression levels in this …
[HTML][HTML] Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
A Schmitt, F Leonardi-Essmann… - European archives of …, 2012 - Springer
Inaccurate wiring and synaptic pathology appear to be major hallmarks of schizophrenia. A
variety of gene products involved in synaptic neurotransmission and receptor signaling are …
variety of gene products involved in synaptic neurotransmission and receptor signaling are …
Scaffold proteins at the postsynaptic density
Scaffold proteins are abundant and essential components of the postsynaptic density (PSD).
They play a major role in many synaptic functions including the trafficking, anchoring, and …
They play a major role in many synaptic functions including the trafficking, anchoring, and …
Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity
X Liu, Z Li, C Fan, D Zhang, J Chen - Journal of medical genetics, 2017 - jmg.bmj.com
The diagnosis of debilitating psychiatric disorders like autism spectrum disorder (ASD) and
schizophrenia (SCHZ) is on the rise. These are severe conditions that lead to social isolation …
schizophrenia (SCHZ) is on the rise. These are severe conditions that lead to social isolation …
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis
BackgroundGenetic studies of single gene variants have been criticized as providing a
simplistic characterization of the genetic basis of illness risk that ignores the effects of other …
simplistic characterization of the genetic basis of illness risk that ignores the effects of other …
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