Background: It has been suggested that the dorsolateral prefrontal cortex (DLPFC),
especially the left DLPFC, has an important role in the pathophysiology and the treatment of …

Objective The perimenopause is associated with an increased risk of developing a major
depressive (MD) episode. The biological changes occurring during perimenopause …

Objectives The role played by medial prefrontal cortex (MPFC) glutamate (Glu) and gamma-
aminobutyric acid (GABA) in the pathophysiology and the treatment of major depression …

Objective Perimenopause is associated with an increased risk of developing a major
depressive (MD) episode. A significant number of women develop their first MD episode …

Objective The anterior cingulate cortex (ACC) is associated with the processing of negative
emotions. Gamma-aminobutyric acid (GABA) metabolism plays an important role in the …

Background Major Depressive Disorder (MDD) is a debilitating disorder that interferes with
successful daily life and functioning, particularly in women, who have a greater prevalence …

Background: It is increasingly being recognized that alterations of the GABAergic system are
implicated in the pathophysiology of depression. This study aimed to explore in vivo gamma …

The medial prefrontal cortex (MPFC) is a key brain area in depressive symptomatology;
specifically, glutamate (Glu) has been reported to play a significant role in major depression …

BACKGROUND: There is growing evidence that the brain gamma-aminobutyric acid (GABA)
system is involved in depression. Lowered plasma GABA levels were identified as a traitlike …

Context Increasing evidence indicates that major depressive disorder (MDD) is associated
with altered function of the major excitatory and inhibitory neurotransmitters glutamate and γ …