The insular cortex is one of the brain regions that show consistent abnormalities in both
structural and functional neuroimaging studies of schizophrenia. In healthy individuals, the …

Involvement of the insular cortex is a common finding in neuroanatomical studies of
schizophrenia, yet its contribution to disease pathology remains unknown. This review …

Theories of schizophrenia propose that abnormal functioning of the neural reward system is
linked to negative and psychotic symptoms, by disruption of reward processing and …

Schizophrenia is characterized by aberrant intrinsic functional connectivity (iFC) within and
between intrinsic connectivity networks (ICNs), including the Default Mode-(DMN), Salience …

Background The insular cortex is connected to a diverse network of cortical and subcortical
areas. This study aimed to investigate whether the diversity in functional connectivity across …

The insular cortex is a limbic integration region that is engaged in emotional and cognitive
functions. To investigate possible insular cortex abnormalities in schizophrenia, we …

In schizophrenia, consistent structural and functional changes have been demonstrated for
the insula including aberrant salience processing, which is critical for psychosis. Interactions …

Background Systems level modeling of functional magnetic resonance imaging data has
demonstrated dysfunction of several large-scale brain networks in schizophrenia. Anomalies …

A large body of neuroimaging literature suggests that distributed regions in the brain form
coordinated largescale networks that show reliable patterns of connectivity when observed …

A salience network, comprising bilateral insula and anterior cingulate cortex (ACC), is
thought to play a role in recruiting relevant brain regions for the processing of sensory …