Glyceraldehyde-3-phosphate dehydrogenase as a target for small-molecule disease-modifying therapies in human neurodegenerative disorders

MD Berry - Journal of Psychiatry and Neuroscience, 2004 - jpn.ca
Recent articles have highlighted numerous additional functions of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH) that are independent of its well-documented glycolytic …

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

DM Chuang, C Hough… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract Increasing evidence supports the notion that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is a protein with multiple functions, including its surprising role in …

Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?

JL Mazzola, MA Sirover - Neurotoxicology, 2002 - Elsevier
Recent evidence reveals that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is not
simply a classical glycolytic protein of little interest. Instead, it is a multifunctional protein with …

Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs

R Ishitani, H Tajima, H Takata, K Tsuchiya… - Progress in Neuro …, 2003 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has long been recognized as a
classical glycolytic protein and has been used as a “housekeeping” gene in studies of …

Reduction of glyceraldehyde‐3‐phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts

JL Mazzola, MA Sirover - Journal of neurochemistry, 2001 - Wiley Online Library
New functions have been identified for glyceraldehyde‐3‐phosphate dehydrogenase
(GAPDH) including its role in neurodegenerative disease and in apoptosis. GAPDH binds …

Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration

DA Butterfield, SS Hardas… - Journal of Alzheimer's …, 2010 - content.iospress.com
Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …

Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weight compounds in counteracting …

J Gerszon, A Rodacka - Ageing research reviews, 2018 - Elsevier
A number of independent studies have shown the contribution of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH) in the pathogenesis of several neurodegenerative …

Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling

WG Tatton, RME Chalmers-Redman, M Elstner… - Advances in Research …, 2000 - Springer
Summary Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-studied
glycolytic enzyme that plays a key role in energy metabolism. GAPDH catalyzes the …

Disclosure of a pro-apoptotic glyceraldehyde-3-phosphate dehydrogenase promoter: anti-dementia drugs depress its activation in apoptosis

K Tsuchiya, H Tajima, M Yamada, H Takahashi… - Life sciences, 2004 - Elsevier
Overexpression and subsequent nuclear accumulation of glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is involved in neuronal apoptosis induced by several stimuli in …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease

N El Kadmiri, I Slassi, B El Moutawakil, S Nadifi… - Pathologie …, 2014 - Elsevier
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme that
catalyzes the sixth step of glycolysis and thus, serves to break down glucose for energy …