Background: Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+)
and glutamic acid decarboxylase (GAD 67) mRNA levels have previously been found to be …

Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased
expression of GABA-related genes such as the 67 kDa isoform of glutamate decarboxylase …

Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of neural functions,
including synaptic plasticity and exhibits activity-dependent regulation of expression. As …

Abnormalities in brain-derived neurotrophic factor (BDNF)/trkB signaling have been
implicated in the etiology of schizophrenia and mood disorders. Patients with schizophrenia …

Several lines of evidence implicate BDNF in the pathophysiology of psychiatric illness.
BDNF polymorphisms have also been associated with the risk of schizophrenia and mood …

The brain-derived neurotrophic factor (BDNF) gene contains multiple 5′ promoters which
generate alternate transcripts. Previously, we found that pan-BDNF mRNA and protein are …

Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived …

Patients with schizophrenia have reduced neurotrophin levels in their dorsolateral prefrontal
cortex (DLPFC) compared to normal unaffected individuals. The tyrosine kinase-containing …

Objective Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF)
plays a critical role in activity-dependent neuroplasticity underlying learning and memory in …

Magnetic resonance (MR) imaging studies have identified hippocampal structural alterations
in the pathogenesis of schizophrenia. Brain-derived neurotrophic factor (BDNF) is one of the …