Responsiveness of 5-HT1A and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition

M El Mansari, P Blier - Journal of Psychiatry and Neuroscience, 2005 - jpn.ca
Background: The only antidepressant drugs that are effective in the treatment of obsessive–
compulsive disorder (OCD) are those that effectively block the reuptake of serotonin (5 …

Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors: relevance to treatment of obsessive-compulsive …

M El Mansari, C Bouchard, P Blier - Neuropsychopharmacology, 1995 - Elsevier
Potent serotonin (5-HT) reuptake inhibitors are the only antidepressant agents thus far
shown to be effective in the treatment of obsessive-compulsive disorder (OCD). Positron …

Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive–compulsive disorder

PBF Bergqvist, C Bouchard, P Blier - Biological psychiatry, 1999 - Elsevier
Background: Among all antidepressant treatments, including electroconvulsive shock (ECS)
therapy and monoamine oxidase inhibitors (MAOIs), only the selective serotonin (5-HT) …

Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors

ME Mansari, C Bouchard, P Blier - Neuropsychopharmacology, 1995 - nature.com
Abstract Potent serotonin (5-HT) reuptake inhibitors are the only antidepressant agents thus
far shown to be effective in the treatment of obsessive-compulsive disorder (OCD). Positron …

Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder

M El Mansari, P Blier - Progress in Neuro-Psychopharmacology and …, 2006 - Elsevier
A significant body of evidence documented that the orbitofrontal cortex (OFC) and the head
of caudate nucleus are involved in the mediation of obsessive-compulsive disorder (OCD) …

Selective increases in serotonin 5-HT1B/1D and 5-HT2A/2C binding sites in adult rat basal ganglia following lesions of serotonergic neurons

V Compan, L Segu, MC Buhot, A Daszuta - Brain research, 1998 - Elsevier
Quantitative autoradiography was used to examine possible adaptive changes in serotonin
5-HT1B/1D and 5-HT2A/2C receptor binding sites in adult rat basal ganglia, after partial or …

The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig

C Roberts, GW Price, BJ Jones - European journal of pharmacology, 1997 - Elsevier
The role of 5-HT1B/1D receptors in modulating extracellular 5-hydroxytryptamine (5-HT)
levels in the guinea pig was investigated with the non-selective 5-HT1B/1D receptor inverse …

Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex

M Matsumoto, H Togashi, K Mori, K Ueno… - European journal of …, 1999 - Elsevier
Endogenous serotonin (5-hydroxytryptamine, 5-HT)-mediated regulation of dopamine
release in the rat prefrontal cortex was pharmacologically characterized using in vivo …

Patients with obsessive–compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei

KH Adams, ES Hansen, LH Pinborg… - International Journal …, 2005 - academic.oup.com
The pharmacological efficacy of serotonergic-acting drugs suggest that patients with
obsessive–compulsive disorder (OCD) may have alterations in their cerebral serotonergic (5 …

Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice

NA Shanahan, LP Velez, VL Masten, SC Dulawa - Biological psychiatry, 2011 - Elsevier
BACKGROUND: Perseveration and sensorimotor gating deficits are core features of
obsessive-compulsive disorder (OCD). Serotonin 1B receptor (5-HT1BR) agonists …