Objective: To examine the effects of short-term valproate treatment on human brain
serotonin and dopamine function by means of challenge tests with ipsapirone, a partial …

Valproate is effective in treating bipolar disorder characterized by rapid cycling or acute
mania, although the mechanism of action is unclear. In contrast to other treatments for …

Hypothermic and hormonal responses to a challenge with a selective 5-HT1A receptor
agonist ipsapirone are considered to provide an index of 5-HT1A receptor function in …

The mechanisms underlying the acute and prophylactic antimanic properties of valproate
have remained elusive. There are some reports that treatment with valproic acid may …

We sought to determine whether patients receiving valproate plus an antidepressant had
significantly lower serum valproate levels before initiation of the antidepressant than those …

Valproate is a well-established anticonvulsant that is increasingly being employed, often in
combination with other psychotropics, for its mood-stabilizing properties. This compound is …

The antiepileptic drug valproate has previously been shown to increase serotonin and
dopamine turnover in certain brain regions, but the role of these alterations in the diverse …

Background: Lamotrigine, a new anticonvulsant, has recently been reported to be effective
in treating patients with bipolar mania, depression, and schizoaffective disorder, suggesting …

Dextroamphetamine administration in healthy controls produces a range of subjective and
physiological effects, which have been likened to those occurring during mania. However, it …

Objectives Off-label prescription of antipsychotics to patients without psychotic symptoms
has become a routine matter for many psychiatrists and also some general practitioners …