Contribution of nonprimate animal models in understanding the etiology of schizophrenia

NL Lazar, RWJ Neufeld, DP Cain - Journal of Psychiatry and Neuroscience, 2011 - jpn.ca
Schizophrenia is a severe psychiatric disorder that is characterized by positive and negative
symptoms and cognitive impairments. The etiology of the disorder is complex, and it is …

An overview of animal models related to schizophrenia

IR Winship, SM Dursun, GB Baker… - The Canadian …, 2019 - journals.sagepub.com
Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Genetic models of schizophrenia and related psychotic disorders: progress and pitfalls across the methodological “minefield”

CMP O'Tuathaigh, PM Moran, JL Waddington - Cell and tissue research, 2013 - Springer
The challenge of modelling a complex and multifaceted disorder such as schizophrenia is
epitomised by the considerable degree of phenotypic variability described in patients and by …

Animal models of developmental neuropathology in schizophrenia

N Kanyuch, S Anderson - Schizophrenia Bulletin, 2017 - academic.oup.com
Schizophrenia is a heterogenous psychotic disorder of undetermined etiologies for which
available treatments are limited. Recent advances in appreciating both genetic and …

[HTML][HTML] Animal models of schizophrenia: a critical review

ER Marcotte, DM Pearson… - Journal of Psychiatry and …, 2001 - ncbi.nlm.nih.gov
Current research into schizophrenia has remained highly fragmented, much like the clinical
presentation of the disease itself. Differing theories as to the cause and progression of …

Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates

A Sawa - Progress in brain research, 2009 - Elsevier
Schizophrenia is a debilitating mental illness in which major initial risks of the disease
during neurodevelopment may disturb postnatal brain maturation, which results in onset …

[BOOK][B] Animal models of schizophrenia and related disorders

P O'Donnell - 2011 - Springer
Animal models of schizophrenia and major psychiatric disorders have been sought for
decades. As it is clear that schizophrenia is a uniquely human disease, animal models are …

Animal models of schizophrenia

JW Young, X Zhou, MA Geyer - Behavioral neurobiology of schizophrenia …, 2010 - Springer
Schizophrenia may well represent one of the most heterogenous mental disorders in human
history. This heterogeneity encompasses (1) etiology; where numerous putative genetic and …

Epidemiology-driven neurodevelopmental animal models of schizophrenia

U Meyer, J Feldon - Progress in neurobiology, 2010 - Elsevier
Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models

M Kvajo, H McKellar, JA Gogos - Neuroscience, 2012 - Elsevier
Schizophrenia is one of the most common psychiatric disorders, but despite progress in
identifying the genetic factors implicated in its development, the mechanisms underlying its …