N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

O Dean, F Giorlando, M Berk - Journal of Psychiatry and Neuroscience, 2011 - jpn.ca
There is an expanding field of research investigating the benefits of alternatives to current
pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful …

The promise of N-acetylcysteine in neuropsychiatry

M Berk, GS Malhi, LJ Gray, OM Dean - Trends in pharmacological sciences, 2013 - cell.com
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of
multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant …

N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects

A Minarini, S Ferrari, M Galletti… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: N-acetylcysteine (NAC) is widely known for its role as a mucolytic
and as an antidote to paracetamol overdose. There is increasing interest in the use of NAC …

[HTML][HTML] The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders

RCJ Bradlow, M Berk, PW Kalivas, SE Back… - CNS drugs, 2022 - Springer
Abstract N-acetyl-L-cysteine (NAC) is a compound of increasing interest in the treatment of
psychiatric disorders. Primarily through its antioxidant, anti-inflammatory, and glutamate …

N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

I Smaga, M Frankowska, M Filip - British Journal of …, 2021 - Wiley Online Library
N‐acetylcysteine (NAC) is a well‐known and safe mucolytic agent, also used in patients with
paracetamol overdose. In addition to these effects, recent preclinical and clinical studies …

[HTML][HTML] N-Acetylcysteine for the treatment of psychiatric disorders: a review of current evidence

SL Ooi, R Green, SC Pak - BioMed Research International, 2018 - hindawi.com
N-acetylcysteine, a sulphur-containing amino acid for the treatment of paracetamol overdose
and chronic obstructive pulmonary disease, is a widely available off-the-shelf oral …

[HTML][HTML] Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review

J Slattery, N Kumar, L Delhey, M Berk, O Dean… - Neuroscience & …, 2015 - Elsevier
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a
mucolytic. Over the past decade, there has been growing evidence for the use of NAC in …

[HTML][HTML] Getting a knack for NAC: N-acetyl-cysteine

RA Sansone, LA Sansone - Innovations in clinical neuroscience, 2011 - ncbi.nlm.nih.gov
Abstract N-acetyl-cysteine, N-acetylcysteine, N-acetyl cysteine, and N-acetyl-L-cysteine are
all designations for the same compound, which is abbreviated as NAC. NAC is a precursor …

N‐acetylcysteine for major mental disorders: a systematic review and meta‐analysis of randomized controlled trials

W Zheng, QE Zhang, DB Cai, XH Yang… - Acta Psychiatrica …, 2018 - Wiley Online Library
Objective This systematic review and meta‐analysis of randomized controlled trials (RCT s)
examined the efficacy and safety of adjunctive N‐acetylcysteine (NAC), an antioxidant drug …

N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

R Bavarsad Shahripour, MR Harrigan… - Brain and …, 2014 - Wiley Online Library
Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …