Background: A naturally occurring loss-of-function mutation in the gene for CC chemokine
receptor type 5 (CCR5-Δ32) has recently been reported as a protective factor in post-stroke …

Background and purpose: The chemokine receptor CCR5 is well known for its function in
immune cells; however, it is also expressed in the brain, where its specific role remains to be …

Ischemic stroke involves a series of complex pathological mechanisms, of which
neuroinflammation is currently the most widely recognized. C–C motif chemokine receptor 5 …

We tested a newly described molecular memory system, CCR5 signaling, for its role in
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …

Background and Purpose—Atherosclerosis is a progressive inflammatory disease and can
develop in large arteries such as carotid and femoral arteries or medium-sized muscular …

Abstract Chemokine (CC motif) receptor 5 (CCR5) is expressed not only in the immune cells
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …

Abstract Background The fractalkine/CX 3 C chemokine receptor 1 (CX 3 CR1) pathway has
been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking …

CCR5 and CXCR4 are structurally related chemokine receptors that belong to the
superfamily of G-protein coupled receptors through which the HIV virus enters and infects …

Background: Stroke is the second leading cause of death and a major cause of disability of
adults worldwide. Inflammatory processes are known to contribute to the pathophysiology of …

Chronic local inflammatory reaction involving reactive microglia is one of the major
pathological events in Alzheimer's disease (AD). There is growing evidence that the …