Neuroplasticity involves synaptic reorganization (Box 1) in response to environmental
stressors or rewards and is thought to underlie our ability to adjust, learn and remember. 7 …

In modern society, depression is one of the most common mental illness; however, its
pathophysiology is not yet fully understood. A great body of evidence suggests that …

Until recently, therapeutic development in psychiatry was targeted solely toward symptom
reduction. While this is a worthwhile goal, it has yielded little progress in improved …

All available antidepressiveVacting molecules are based on the empirical discoveries of the
clinical efficacy of two classes of compounds, the tricyclic antidepressants (TCAs) and the …

Depression is a common chronic psychiatric disorder that is also often co-morbid with
numerous neurological and immune diseases. Accumulating evidence indicates that …

Major depressive disorder is a common, impairing, costly illness that represents the leading
cause of disability worldwide (1). In 2020 in the United States, an estimated 14.8 million …

Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with
alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Neural plasticity is considered the neurophysiological correlate of learning and memory,
although several studies have also noted that it plays crucial roles in a number of …

Twenty years ago, cognitive impairments were recognized as an unmet treatment need in
schizophrenia. Basic science discoveries in neuroplasticity had led to cognitive training …