Background Threat anticipation engages neural circuitry that has evolved to promote
defensive behaviours; perturbations in this circuitry could generate excessive threat …

Background While translational theories link neurodevelopmental changes in threat learning
to pathological anxiety, findings from studies in patients inconsistently support these …

Excessive expression of fear responses in anticipation of threat occurs in anxiety, but
understanding of underlying pathophysiological mechanisms is limited. Animal research …

Excessive fear responses to uncertain threat are a key feature of anxiety disorders (ADs),
though most mechanistic work considers adults. As ADs onset in childhood and confer risk …

Background Owing to high heterogeneity and comorbidity, the shared and unique neural
mechanisms underlying the development of anxiety and major depressive disorders remain …

There is a need to identify brain connectivity alterations predictive of transdiagnostic
processes that may confer vulnerability for affective symptomology. Here, we tested whether …

Adolescent anxiety is common and impairing and often persists into adulthood. There is
growing evidence that adult anxiety is characterized by abnormal fear responses to threat …

Anticipatory emotional responses play a crucial role in preparing individuals for impending
challenges. They do this by triggering a coordinated set of changes in behavioral …

Anxiety is common in adolescence and has been linked to a plethora of negative outcomes
across development. While previous studies of anxiety have focused on threat sensitivity …

In the research field of anxiety, previous studies generally focus on emotional responses
following threat. A recent model of anxiety proposes that altered anticipation prior to …