Background: Dysfunction of glutamate neurotransmission has been implicated in the
pathology of schizophrenia and bipolar disorder, and one mechanism by which glutamate …

Posttranscriptional editing of mRNA is a phenomenon that generates molecular
heterogeneity and functional variety. With the intention to test if RNA editing plays a role in …

Animal studies and cell culture experiments demonstrated that posttranscriptional editing of
the transcript of the GluR-2 gene, resulting in substitution of an arginine for glutamine in the …

Schizophrenia and bipolar disorder (BPD) are common neurodevelopmental disorders,
characterized by various life-crippling symptoms and high suicide rates. Multiple studies …

Background Pre-mRNAs of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propanoic acid
(AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as …

Editing of mRNA in the coding region of the second transmembrane domain of glutamate
receptor subunits GluR2, GluR5, and GluR6 involves a change of the base A in genomic …

Marked reduction of RNA editing at the glutamine (Q)/arginine (R) site of the glutamate
receptor subunit type 2 (GluR2) in motor neurons may be a contributory cause of neuronal …

RNA editing critically regulates neurodevelopment and normal neuronal function. The global
landscape of RNA editing was surveyed across 364 schizophrenia cases and 383 control …

Editing and alternative splicing of mRNA are posttranscriptional steps probably involved in
pathophysiological aspects of epilepsy. The present study analyses the α-amino-3-hydroxy …

In the present series of experiments we compared the up-regulation of GluR5 and GluR6
mRNA editing during the transition from the embryonic to the adult state with changes in the …