A new wave in the genetics of psychiatric disorders: the copy number variant tsunami

R Joober, P Boksa - Journal of Psychiatry and Neuroscience, 2009 - jpn.ca
Because genes are major determinants of psychiatric disorders, our community is hoping
that, as in many other branches of medicine, 1 molecular genetics will lead to important …

Copy number variants: a new molecular frontier in clinical psychiatry

D Moreno-De-Luca, JF Cubells - Current psychiatry reports, 2011 - Springer
Molecular genetic research, building on genetic epidemiology, has provided the field of
psychiatry with a host of exciting advances. It is now clear beyond any reasonable doubt that …

After GWAS: searching for genetic risk for schizophrenia and bipolar disorder

ES Gershon, N Alliey-Rodriguez… - American Journal of …, 2011 - Am Psychiatric Assoc
Ten years ago it was widely expected that the genetic basis of common disease would be
resolved by genome-wide association studies (GWAS), large-scale studies in which the …

[HTML][HTML] CNVs: harbingers of a rare variant revolution in psychiatric genetics

D Malhotra, J Sebat - Cell, 2012 - cell.com
The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.
Genome-wide studies of copy number variation (CNV) have given rise to a new …

A quarter century of progress in psychiatric genetics

JW Smoller - Harvard review of psychiatry, 2017 - journals.lww.com
Downloaded from by BhDMf5ePHKbH4TTImqenVA+ lpWIIBvonhQl60EtgtdlLYrLzSPu+
hQedJnbNaXBf on 11/27/2023 enabled an “unbiased” search for risk loci by examining …

Polygenic heterogeneity: a complex model of genetic inheritance in psychiatric disorders

JJH Rucker, P McGuffin - Biological psychiatry, 2010 - biologicalpsychiatryjournal.com
Shields (1). They proposed, following on from the seminal work of Falconer (2), that what is
inherited is not so much a disorder as a liability to disorder contributed to by multiple genetic …

Selected summaries from the XVI World Congress of Psychiatric Genetics, Osaka, Japan, 11–15 October 2008

S Bergen, J Chen, E Dagdan, TS Foon… - Psychiatric …, 2009 - journals.lww.com
Abstract The XVI World Congress of Psychiatric Genetics, sponsored by the International
Society of Psychiatric Genetics took place in Osaka, Japan, October 2008. Approximately …

[HTML][HTML] Increasing the clinical psychiatric knowledge base about pathogenic copy number variation

PF Sullivan, MJ Owen - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Specific copy number variants (CNVs) have been robustly associated with intellectual
disability, autism, and schizophrenia. Most of the focus in the literature has been on …

Brain copy number variants and neuropsychiatric traits

JR Lupski - Biological psychiatry, 2012 - biologicalpsychiatryjournal.com
In this issue of Biological Psychiatry, genomic analysis of patients with neuropsychiatric
disease reveals the presence of rare copy number variants (CNVs) in about 2% of the …

Polygenicity in psychiatry—like it or not, we have to understand it

MJ Gandal, DH Geschwind - Biological Psychiatry, 2021 - biologicalpsychiatryjournal.com
The subjective and symptomatic basis of psychiatric diagnoses—coupled with high rates of
comorbidity, clinical heterogeneity, and the overwhelming complexity of the human brain …