The psychopharmacology of major psychiatric disorders involves the principle of optimal
treatment, which includes appropriate drug selection, correct dosing, recognition and …

Pharmacodynamic stressors are probably associated with discontinuation of maintenance
treatments with medicinal agents, especially with abrupt discontinuation. In agreement with …

To the Editor: Michael Bauer, MD, Ph. D., et al.(1) added to the compelling evidence that the
supplementation of antidepressant treatment with lithium can enhance response in many …

Antipsychotics, both the long established typical drugs and the recently introduced atypical
drugs clozapine and risperidone, are highly effective in acute and maintenance treatment of …

In this paper, I argue that the problems that occur after discontinuation or reduction of long-
term psychiatric drug treatment may be caused by the process of drug withdrawal itself …

Reports in this issue of Psychotherapy and Psychosomatics by Drs. Cohen and Recalt
document the occurrence of treatment discontinuation in therapeutic trials involving most …

There is abundant evidence for substantial long-term prophylactic efficacy of lithium in
bipolar manic-depressive disorders. Interruption of such treatment carries an extraordinarily …

Background: Gradual discontinuation of lithium may reduce high risk of early morbidity in
bipolar disorder patients discontinuing successful long-term maintenance on lithium, but …

DISCUSSION A search of current psychiatric literature reveals multiple studies and case
reports of refractory bipolar disorder occurring after the discontinuation of lithium therapy. 5 …

To the Editor: We recently discovered an artifact bearing on the effects of time from illness
onset to the start of lithium maintenance treatment and measures of treatment …