The acute phase of depression is often accompanied by anxiety, irritability, insomnia and
anxiety disorders. As a result, the concomitant use of an anxiolytic agent with an …

Antidepressants have proven efficacy in the treatment of acute depressive episodes and the
prevention of relapse over the long-term. However, whether due to ignorance about the …

The prevalence of depression and concomitant anxiety is high in the community. Patients
with depression and concomitant anxiety experience increased functional disability …

The English language literature on the use of benzodiazepines in depressive disorders was
reviewed. We selected double-blind random assignment studies in which benzodiazepines …

Antidepressants lead to improvement in about 70% of unselected patients with a depressive
syndrome. However, many of these patients would also improve with the passage of time …

Objective: Combining antidepressants (ADs) for therapy of acute depression is frequently
employed, but randomized studies have yielded conflicting results. We conducted a …

To the Editor: We read with great interest the article by Dr. Rush et al. on the Combining
Medications to Enhance Depression Outcomes (CO-MED) study (1) and the editorial by Dr …

Remission of a patient's index major depressive episode is essential in preventing a
recurrent orchronic depressive course. Once remission is established, the subsequent goal …

Various pharmacological strategies have been developed to treat such refractory
depression, of which combination therapies with antidepressants are one of the most …

Background: Anxiety frequently coexists with depression, and benzodiazepines are often
prescribed together with antidepressants. However, benzodiazepines themselves have little …