The acute tryptophan depletion (ATD) technique has been used extensively to study the
effect of low serotonin in the human brain. This review assesses the validity of a number of …

Objective: Acute tryptophan depletion (ATD) is an experimental technique that has been
widely used over the last decade to investigate the role of serotonin (5-HT) in a variety of …

BackgroundOver the past 10 years the technique of tryptophan depletion has been used
increasingly as a tool for studying brain serotonergic systems. AimsTo review the technique …

Objective: This is the second of two articles reviewing the modern dietary technique of acute
tryptophan depletion (ATD), a method of transiently reducing central serotonin levels in both …

Rationale There is a growing psychopharmacological literature on the use of Acute
Tryptophan Depletion (ATD) for experimental modulation of the serotonergic system. To …

Evidence that the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays a role in the
pathophysiology of mood disorders has been accumulating over the past three decades …

Acute tryptophan depletion (ATD) studies have been used to assess the role of the
serotonergic system in various aspects of human behaviour. Changes in mood have already …

The method of acute tryptophan depletion (ATD), which reduces the availability of the
essential amino acid tryptophan (TRP), the dietary serotonin (5-hydroxytryptamine (5-HT)) …

Acute tryptophan depletion (ATD), a method to temporarily lower central serotonin levels,
has been used to study the functioning of the serotonergic system. Relatively recent studies …

Serotonin (5-HT, 5-hydroxytryptamine) may have an important role in the maintenance of
normal neuropsychological functioning. The method of acute tryptophan depletion (ATD) …