Background: Abnormally high activity in the lateral habenula causes anxiety-or depression-
like behaviours in animal experimental models. It has also been reported in humans that …

Objective This study systematically investigated the effect of chronic mild stress and
response to antidepressant treatment in the lateral habenula at the whole genome level …

Early life stress can result in depression in humans and depressive-like behaviour in
rodents. In various animal models of depression, the lateral habenula (LHb) has been …

Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset, neurodevelopmental
disorder, whereas major depressive disorder (MDD) is a mood disorder that typically …

The habenula is activated in response to stressful and aversive events, resulting in
exploratory inhibition. Although possible mechanisms for habenula activation have been …

Recent studies have implicated the habenula in modulating states of arousal and chronic
responses to stress. We examined whether lesion of the habenula efferent pathway, the …

Background The habenula plays an important role on cognitive and affective functions by
regulating monoamines transmission such as the dopamine and serotonin, such that its …

Background Preclinical studies showed that prenatal stress (PNS) induces behavioral
alterations, although not all the exposed animals show a vulnerable phenotype. Recent …

The habenula is an evolutionarily conserved structure in the vertebrate brain. Lesion and
electrophysiological studies in animals have suggested that it is involved in the regulation of …

Chronic stress contributes to the risk of developing depression; the habenula, a nucleus in
epithalamus, is associated with many neuropsychiatric disorders. Using genome-wide gene …