Objective: High-field strength proton magnetic resonance spectroscopy (1 H-MRS) and
peripheral blood analyses reported in the literature reveal glutamate (Glu) and glutamine …

Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and
cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides …

Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …

Background: Positron emission tomographic and postmortem studies comparing
schizophrenic patients with healthy control subjects have found medial prefrontal cortical …

To the Editor: As schizophrenia researchers specializing in the use of brain MRS, we
present our shared concerns regarding the results of van Elst et al.(2005) published in …

Background Recent magnetic resonance spectroscopy (MRS) studies report that glutamine
is altered in the brains of schizophrenic patients. There were also conflicting findings on …

OBJECTIVE: This in vivo 1H magnetic resonance spectroscopy study examined levels of
glutamate, glutamine, and N-acetylaspartate in patients experiencing their first episode of …

Both glutamine (Gln) and glutamate (Glu) are known to exist in plasma and brain. However,
despite the assumed relationship between brain and plasma, no studies have clarified the …

BACKGROUND: Glutamatergic dysfunction has been implicated in the pathophysiology of
schizophrenia. However, so far there is limited direct evidence of altered in vivo glutamate …

OBJECTIVE: This in vivo 1H magnetic resonance spectroscopy study examined levels of
glutamate, glutamine, and N-acetylaspartate in medicated patients with chronic …