Background: Oxidative damage in the central nervous system is increasingly recognized as
an important pathological process in many diseases. Previously, our laboratory found that …

Schizophrenia is associated with a substantially increased somatic morbidity and mortality,
which may partly be caused by accelerated cellular aging. Oxidative stress is an established …

BACKGROUND: Depression has been associated with increased oxidative stress and
hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the …

Bipolar disorder (BD) is a mental disorder characterized by recurrent relapses of affective
episodes, cognitive impairment, illness progression, and reduced life expectancy. Increased …

Background: Increased oxidative stress is strongly implicated in bipolar disorder (BD), where
protein oxidation, lipid peroxidation and oxidative damage to DNA have been consistently …

Oxidative stress has an important place in studies investigating the pathophysiology of
psychiatric diseases. In spite of this fact, longitudinal studies are required to clarify the …

Objective The authors investigated the idea that some patients with schizophrenia exhibit a
chronic, deteriorating course without showing frank neurodegeneration at postmortem …

Increasing evidence suggests that oxidative stress is associated with normal aging and
several neurodegenerative diseases, including Alzheimer's disease (AD). Here we …

In this study we used an in situ approach to identify the oxidized nucleosides 8-
hydroxydeoxyguanosine (8OHdG) and 8-hydroxyguanosine (8OHG), markers of oxidative …

Oxidative stress may contribute to neuronal loss in Alzheimer's disease (AD). The present
study compares the levels of oxidative damage to proteins, lipids, and DNA bases from …