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Scaffold Proteins at the Postsynaptic Density

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Synaptic Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((volume 970))

Abstract

Scaffold proteins are abundant and essential components of the postsynaptic density (PSD). They play a major role in many synaptic functions including the trafficking, anchoring, and clustering of glutamate receptors and adhesion molecules. Moreover, they link postsynaptic receptors with their downstream signaling proteins and regulate the dynamics of cytoskeletal structures. By definition, PSD scaffold proteins do not have intrinsic enzymatic activities but are formed by modular and specific domains deputed to form large protein networks. Here, we will discuss the latest findings regarding the structure and functions of major PSD scaffold proteins.

Given that scaffold proteins are central components of PSD architecture, it is not surprising that deletion or mutations in their human genes cause severe neuropsychiatric disorders including autism, mental retardation, and schizophrenia. Thus, their dynamic organization and regulation are directly correlated with the essential structure of the PSD and the normal physiology of neuronal synapses.

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Authors and Affiliations

  1. CNR Institute of Neuroscience, Department of Pharmacology, University of Milan and Neuromuscular Diseases and Neuroimmunology, Neurological Institute Foundation Carlo Besta, Via Vanvitelli 32, 20129, Milan, Italy

    Chiara Verpelli & Carlo Sala

  2. Institute of Anatomy and Cell Biology, Ulm University Faculty of Medicine, Albert Einstein Allee 11, 89081, Ulm, Germany

    Michael J. Schmeisser & Tobias M. Boeckers

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  1. Chiara Verpelli
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  2. Michael J. Schmeisser
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  3. Carlo Sala
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  4. Tobias M. Boeckers
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Correspondence to Carlo Sala or Tobias M. Boeckers .

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  1. , PG Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestraße 6, Magdeburg, 39118, Germany

    Michael R. Kreutz

  2. , Institute of Neuroscience, CR6 CNR-IN Consiglio Nazionale delle Ric, Via Vanvitelli, 32, Milano, 20129, Italy

    Carlo Sala

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Verpelli, C., Schmeisser, M.J., Sala, C., Boeckers, T.M. (2012). Scaffold Proteins at the Postsynaptic Density. In: Kreutz, M., Sala, C. (eds) Synaptic Plasticity. Advances in Experimental Medicine and Biology, vol 970. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0932-8_2

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