JPN

Welcome to the online edition of the Journal of Psychiatry and Neuroscience, the official journal of the Canadian College of Neuropsychopharmacology.

Latest Articles

Small animal imaging presents an opportunity for improving translational research in biological psychiatry

Improving longitudinal methodologies such that they integrate more translationally relevant behaviour is critical to creating more robust models of neuropsychiatric disorders.
BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization

BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization.
The utility of maraviroc, an antiretroviral agent used to treat HIV, as treatment for opioid abuse? Data from MRI and behavioural testing in rats

Maraviroc is an ARV and CCR5-antagonist used to treat HIV. CCR5/μ-opioid receptor heterodimerization suggests that maraviroc could treat oxycodone abuse. It attenuates oxycodone-seeking and reduces functional coupling in the reward circuitry.
Cannabis use and resting state functional connectivity in adolescent bipolar disorder

Study findings provide preliminary evidence of cannabis-related differences in functional reward circuits in adolescents with bipolar disorder.
Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide

Protein and mRNA expression of NLRP1, NLRP3, NLRP6, caspase3 and ASC were increased in the postmortem brains of people who were depressed and died by suicide, and these may play an important role in the pathophysiology of depression and suicide.