Welcome to the online edition of the Journal of Psychiatry and Neuroscience, the official journal of the Canadian College of Neuropsychopharmacology.
Latest Articles
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In this fMRI study, a load-dependent inverted U–shaped connectivity of the default mode network was observed in patients with schizophrenia during an n-back working-memory task.
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Signal propagation from the left dlPFC to the salience network was reduced in patients with TRD. This reduction may have been associated with decreased gene expression of oligodendrocytes.
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A patient's case spotlights the relevance of MAOIs for treatment-resistant depression and the need for clinicians to remain hopeful when patients aren't.
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In an fMRI approach-avoidance conflict task, adults with anxiety or depression showed aberrant neural activity in the amygdala and striatum compared to healthy adults. Study findings point towards striatal reactivity as a treatment target.
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Reduced neural activation in the orbitofrontal and insular cortex is associated with anhedonia in major depression. It is more pronounced with aversive stimuli during loss processing than it is during reward processing.
