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Welcome to the online edition of the Journal of Psychiatry and Neuroscience, the official journal of the Canadian College of Neuropsychopharmacology.

  • Photo of a young Black man looking at a computer screen
    Research
    Reward and loss processing with anhedonia in MDD
  • Assorted packages of antidepressant pills
    Editorial
    Genomics and brain imaging
  • Genomic data visualization. Gene mapping, DNA sequencing, genome barcoding, genetic marker map analysis infographic vector concept
    Research
    Antidepressants for symptoms of autism spectrum disorder
  • 3D illustration of prenatal alcohol consumption. Beer, wine and whiskey beverages in the foreground and illustration of fetus in background. Concept suggesting the harms of alcohol consumption during pregnancy.
    Research
    Prenatal alcohol exposure and the structure of the rostral cingulate cortex
  • Call for submissions
    Call for submissions
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  • 3
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Latest Articles

  • Understanding the neurobiological basis of anhedonia in major depressive disorder — evidence for reduced neural activation during reward and loss processing
    Reduced neural activation in the orbitofrontal and insular cortex is associated with anhedonia in major depression. It is more pronounced with aversive stimuli during loss processing than it is during reward processing.
  • Clinical opportunity awaits at the intersection of genomics and brain imaging
    Our latest editorial shines light on the potential brain imaging genetics holds in understanding the largely elusive pathophysiology of neuropsychiatric disorders.
  • Therapeutic effects of antidepressants for global improvement and subdomain symptoms of autism spectrum disorder: a systematic review and meta-analysis
    This meta-analysis found that antidepressants were effective for restricted and repetitive behaviours, global symptoms and different symptom subdomains of autism spectrum disorders. Low symptom severity and adulthood were associated with better outcomes.
  • Effects of prenatal alcohol exposure on neurobehavioural development and volume of rostral cingulate cortex subregions
    Children with prenatal alcohol exposure show volumetric reductions in the pregenual anterior cingulate cortex that appear to underlie altered behaviour and emotions.
  • Higher glutamatergic activity in the medial prefrontal cortex in chronic ketamine users
    The mPFC is an important brain region in depression and addiction. Using proton magnetic resonance spectroscopy, this study found that chronic ketamine users have increased glutamatergic activity in the mPFC.
More recent content  
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  • Hepatitis C–associated late-onset schizophrenia: a nationwide, population-based cohort study
  • Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosis
  • Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence
  • Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
  • Systematic review of the neural basis of social cognition in patients with mood disorders
More...

Issue in Progress​

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November-December 2021

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Copyright 2022, CMA Impact Inc. or its licensors. All rights reserved. ISSN 1180-4882.

All editorial matter in JPN represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.
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