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The Na+-dependence of Na+-activated K+-channels (IK(Na)) in guinea pig ventricular myocytes, is different in excised inside/out patches and cell attached patches

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  • Excitable Tissues and Central Nervous Physiology
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Abstract

Single Na+-activated K+-channels were recorded from intact guinea-pig ventricular myocytes perfused with Ca-free, Mg-free Tyrode, to increase [Na+]i. The activity of these channels increases with the time of perfusion with this solution and decreases when the bathing sodium is reduced. The activity of the Na+-activated K+-channel is greater in the cell attached patches than from excised cell free patches, at the same [Na+]. It is suggested that this K+ channel is significantly active in intact cells within the physiological range of [Na]i.

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Authors and Affiliations

  1. Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK

    Glenn C. Rodrigo

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  1. Glenn C. Rodrigo
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Rodrigo, G.C. The Na+-dependence of Na+-activated K+-channels (IK(Na)) in guinea pig ventricular myocytes, is different in excised inside/out patches and cell attached patches. Pflugers Arch. 422, 530–532 (1993). https://doi.org/10.1007/BF00375082

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  • DOI: https://doi.org/10.1007/BF00375082

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