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State-dependent microstructural white matter changes in bipolar I depression

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

Abnormalities in fronto-limbic-striatal white matter (WM) have been reported in bipolar disorder (BD), but results have been inconsistent across studies. Furthermore, there have been no detailed investigations as to whether acute mood states contribute to microstructural changes in WM tracts. In order to compare fiber density and structural integrity within WM tracts between BD depression and remission, whole-brain fractional anisotropy (FA) and mean diffusivity (MD) were assessed in 37 bipolar I disorder (BD-I) patients (16 depressed and 21 remitted), and 26 healthy individuals with diffusion tensor imaging. Significantly decreased FA and increased MD in bilateral prefronto-limbic-striatal white matter and right inferior fronto-occipital, superior and inferior longitudinal fasciculi were shown in all BD-I patients versus controls, as well as in depressed BD-I patients compared to both controls and remitted BD-I patients. Depressed BD-I patients also exhibited increased FA in the ventromedial prefrontal cortex. Remitted BD-I patients did not differ from controls in FA or MD. These findings suggest that BD-I depression may be associated with acute microstructural WM changes.

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Acknowledgments

This study was supported in part by 1 R01 MH076971-01 (M.L.P.) and NARSAD Independent Investigator Award (Nellie Blumenthal Investigator) to M.L.P.

Conflict of interest statement

None.

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Authors and Affiliations

  1. Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, University of São Paulo Medical School, Centro de Medicina Nuclear, 3° andar, LIM-21, Rua Dr. Ovídio Pires de Campos, s/n, São Paulo, SP, 05403-010, Brazil

    Marcus V. Zanetti, Fábio L. S. Duran & Geraldo F. Busatto

  2. Department of Computational Sciences, Institute of Mathematics and Statistics, University of São Paulo, Rua do Matão, 1010, Bloco C, Sala 10, São Paulo, SP, 05508-090, Brazil

    Marcel P. Jackowski

  3. Functional Neuroimaging in Emotional Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Loeffler Building, 121 Meyran Ave., Pittsburgh, PA, 15213, USA

    Amelia Versace, Jorge R. C. Almeida, Stefanie Hassel, David J. Kupfer & Mary L. Phillips

  4. Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff University School of Medicine, Academic Avenue, Heath Park, Cardiff, CF14 4XN, UK

    Mary L. Phillips

Authors
  1. Marcus V. Zanetti
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Correspondence to Geraldo F. Busatto.

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Zanetti, M.V., Jackowski, M.P., Versace, A. et al. State-dependent microstructural white matter changes in bipolar I depression. Eur Arch Psychiatry Clin Neurosci 259, 316–328 (2009). https://doi.org/10.1007/s00406-009-0002-8

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  • DOI: https://doi.org/10.1007/s00406-009-0002-8

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