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Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM

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Summary.

We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated patients with major depression and 13 healthy controls were examined by [123I]-ADAM SPECT. The midbrain SERT availability (SERT V3″) was calculated using individual MRI scans. In 13/21 patients SPECT was repeated 7 days after oral medication with citalopram (10 mg/day). We found no significant difference in the mean midbrain SERT availability between the studied patients with major depression and healthy controls (0.86 ± 0.27 vs. 0.71 ± 0.44, p = 0.069). The mean SERT occupancy accounted to 61%. The degree of SERT blockade by citalopram did not correlate with the reduction in HAMD total score. Treatment with low-dosed citalopram caused individually variable occupancy of the midbrain-SERT and a rapid clinical improvement in 54% of the investigated patients.

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Authors and Affiliations

  1. Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow, Berlin, Germany

    N. Herold, H. Amthauer, L. Luedemann, H. Bruhn, R. Felix & M. Plotkin

  2. Department of Psychiatry, Campus Mitte, Charité Universitätsmedizin, Berlin, Germany

    K. Uebelhack, L. Franke & R. Uebelhack

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  1. N. Herold
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  2. K. Uebelhack
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  3. L. Franke
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  4. H. Amthauer
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  7. R. Felix
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Herold, N., Uebelhack, K., Franke, L. et al. Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM. J Neural Transm 113, 659–670 (2006). https://doi.org/10.1007/s00702-005-0429-7

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