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Schizophrenic women with the APOE ε4 allele have a worse prognosis than those without it

Molecular Psychiatry volume 6, pages 307–310 (2001)Cite this article

Abstract

The ε4 allele of APOE is generally accepted to be a risk factor in Alzheimer's disease and it has been related to other neuropsychiatric disorders, including schizophrenia. The results of several case-control studies have been inconclusive. To shed more light on this issue we carried out an association study that compared the APOE common variant in a group of 365 schizophrenia patients and 584 controls. We found no differences in the genotype distributions and allele frequencies of patients and controls. In the group of patients, we also analysed the possible influence of the ε4 allele in the clinical variables. The most important findings are that the age at onset (AAO) of ε4+ schizophrenic women, those that have one or two ε4 alleles, is 4 years earlier than that of ε4− women and their risk of suffering a negative syndrome subtype is four times greater. This was not found in schizophrenic men. Our results show that the APOE variant is not a risk factor for developing schizophrenia but that it may modulate its phenotypic expression in a sex-dependent manner.

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Acknowledgements

This work was supported in part by grant FIS 98/1433. Carmen Virgos is a predoctoral fellow financed by the Comissionat per a Universitats i Recerca.

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Authors and Affiliations

  1. Departament de Formació i Investigació, Hospital Psiquiàtric Universitari Institut Pere Mata, Ctra de I'Institut Pere Mata s/n, Reus, 43206, Spain

    L Martorell, C Virgos, J Valero, G Coll, L Figuera, A Labad & E Vilella

  2. Unitat de Psiquiatria i Psicologia Mèdica, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, Reus, 43201, Spain

    L Martorell, C Virgos, J Valero, L Figuera, A Labad & E Vilella

  3. Centre de Recerca Biomèdica, Hospital Universitari Sant Joan de Reus, C/Sant Joan s/n, Reus, 43201, Spain

    J Joven & E Vilella

  4. Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Pza San Francisco s/n, Zaragoza, 50009, Spain

    M Pocoví

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  1. L Martorell
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  2. C Virgos
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  8. A Labad
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  9. E Vilella
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Correspondence to E Vilella.

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Martorell, L., Virgos, C., Valero, J. et al. Schizophrenic women with the APOE ε4 allele have a worse prognosis than those without it. Mol Psychiatry 6, 307–310 (2001). https://doi.org/10.1038/sj.mp.4000855

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  • DOI: https://doi.org/10.1038/sj.mp.4000855

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