Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways

Y Cao, X Mao, C Sun, P Zheng, J Gao, X Wang… - Brain research …, 2011 - Elsevier
Baicalin is an important medicinal herb purified from the dry roots of Scutellaria baicalensis
Georgi. The present study was undertaken to evaluate the neuroprotective effects of baicalin …

Potential serum biomarkers from a metabolomics study of autism

H Wang, S Liang, M Wang, J Gao, C Sun, J Wang… - Journal of Psychiatry and …, 2016 - jpn.ca
Background: Early detection and diagnosis are very important for autism. Current diagnosis
of autism relies mainly on some observational questionnaires and interview tools that may …

Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways

L Ba, J Gao, Y Chen, H Qi, C Dong, H Pan, Q Zhang… - Phytomedicine, 2019 - Elsevier
Background Cardiac hypertrophy is an adaptive response of the myocardium to pressure or
volume overload. Recent evidences indicate that allicin can prevent cardiac hypertrophy. …

Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism

H Wu, X Wang, J Gao, S Liang, Y Hao, C Sun, W Xia… - Life sciences, 2017 - Elsevier
Aims To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism.
Main methods As an animal model of autism, we used intraperitoneal injection of VPA on …

Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model

J Gao, X Wang, H Sun, Y Cao, S Liang, H Wang… - International journal of …, 2016 - Elsevier
Prenatal exposure to valproic acid (VPA) in rat offspring is capable of inducing experimental
autism with neurobehavioral aberrations. This study investigated the effect of …

Allicin improves the function of cardiac microvascular endothelial cells by increasing PECAM-1 in rats with cardiac hypertrophy

P Shi, Y Cao, J Gao, B Fu, J Ren, L Ba, C Song, H Qi… - Phytomedicine, 2018 - Elsevier
Objective Cardiac microvascular damage is significantly associated with the development of
cardiac hypertrophy (CH). Researchers found that allicin could inhibit CH, but the …

Lutein suppresses ferroptosis of cardiac microvascular endothelial cells via positive regulation of IRF in cardiac hypertrophy

…, G Yang, S Huo, J Wu, P Ren, Y Cao, J Gao… - European Journal of …, 2023 - Elsevier
Cardiac microvascular dysfunction contributes to cardiac hypertrophy (CH) and can progress
to heart failure. Lutein is a carotenoid with various pharmacological properties, such as anti-…

Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid

J Gao, H Wu, Y Cao, S Liang, C Sun, P Wang… - The Journal of …, 2016 - Elsevier
Docosahexaenoic acid (22:6n-3; DHA) is known to play a critical role in postnatal brain
development. However, there have been no studies investigating the preventive effect of DHA on …

Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens

C Yong‐gang, J Shan, L Lei, G Jingquan… - Phytotherapy …, 2010 - Wiley Online Library
Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular
system. This study was designed to evaluate the antiarrhythmic effects as well as the …

Activation of transient receptor potential vanilloid 3 channel (TRPV 3) aggravated pathological cardiac hypertrophy via calcineurin/NFAT c3 pathway in rats

…, P Shi, C Song, L Ba, Y Chen, J Gao… - Journal of cellular …, 2018 - Wiley Online Library
Cardiac hypertrophy is a compensatory response to mechanical stimuli and neurohormonal
factors, ultimately progresses to heart failure. The proteins of some transient receptor …