Article Figures & Tables
Tables
Variable Reference range Pneumonia Vaccination 3 months previous 3 days prior 4 days after 5 days after 6 days after Leukocyte count, × 109/L 4.0–11.0 8.4 5.7 11.1 6.3 — Neutrophils, × 109/L 2.0–8.0 6.3 2.7 9.1 4.3 — Monocytes, × 109/L 0.1–0.8 0.7 0.5 0.9 0.6 — Lymphocytes, × 109/L 1.0–4.0 1.3 2.3 1.1 1.5 — High-sensitivity CRP, mg/L ≤ 7.5‡ 65.6§ — 160.1 101.6 32.5 Clozapine dose, mg/d 500 300 300 0 0 Clozapine, nM/L (US ng/mL) 1070 (350)¶ 3984 (1302) 1630 (533) 3296 (1078) 1212 (396) Norclozapine, nM/L (US ng/mL) 1343 (439) 586 (192) 880 (288) 773 (253) C/N* ≤ 2 2.95 2.78 3.75 1.57 C/D† 0.6–1.2 2.6 1.8 3.6 2.2 CRP = C-reactive protein.
↵* Ratio of clozapine to norclozapine level, value > 2 indicates slow metabolism.
↵† Ratio of clozapine level in ng/mL to clozapine dose in mg; requires a steady state or mean of 5 previous days used, a higher value indicates lower clearance.
↵‡ Higher value indicates active inflammation or infection.
↵§ Previous baseline 4.1; recovered in 6 days to 5.8.
↵¶ Therapeutic level.