Skip to main content

Main menu

  • Home
  • Issues
    • Issue in progress
    • Issues by date
  • Sections
    • Editorial
    • Review
    • Research
    • Commentary
    • Psychopharmacology for the Clinician
    • Letters to the Editor
  • Topic Collections
  • Instructions for authors
    • Overview for authors
    • Submission checklist
    • Editorial policies
    • Publication fees
    • Submit a manuscript
    • Dr. Francis Wayne Quan Memorial Prize
    • Open access
  • Alerts
    • Email alerts
    • RSS
  • About
    • General information
    • Staff
    • Editorial Board
    • Contact
  • CMAJ JOURNALS
    • CMAJ
    • CMAJ Open
    • CJS
    • JAMC

User menu

Search

  • Advanced search
JPN
  • CMAJ JOURNALS
    • CMAJ
    • CMAJ Open
    • CJS
    • JAMC
JPN

Advanced Search

  • Home
  • Issues
    • Issue in progress
    • Issues by date
  • Sections
    • Editorial
    • Review
    • Research
    • Commentary
    • Psychopharmacology for the Clinician
    • Letters to the Editor
  • Topic Collections
  • Instructions for authors
    • Overview for authors
    • Submission checklist
    • Editorial policies
    • Publication fees
    • Submit a manuscript
    • Dr. Francis Wayne Quan Memorial Prize
    • Open access
  • Alerts
    • Email alerts
    • RSS
  • About
    • General information
    • Staff
    • Editorial Board
    • Contact
  • Subscribe to our alerts
  • RSS feeds
  • Follow JPN on Twitter
Research Paper
Open Access

Depressive rumination is correlated with brain responses during self-related processing

Tzu-Yu Hsu, Tzu-Ling Liu, Paul Z. Cheng, Hsin-Chien Lee, Timothy J. Lane and Niall W. Duncan
J Psychiatry Neurosci September 21, 2021 46 (5) E518-E527; DOI: https://doi.org/10.1503/jpn.210052
Tzu-Yu Hsu
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tzu-Ling Liu
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Z. Cheng
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hsin-Chien Lee
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timothy J. Lane
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niall W. Duncan
From the Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan (Hsu, Liu, Cheng, Lane, Duncan); the Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan (Hsu, Cheng, Lane, Duncan); the Institute of Cognitive Neuroscience, National Central University, Zhongda, Taiwan (Liu); the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (Lee); and the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (Lee)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Related Content
  • Responses
  • Metrics
  • PDF
Loading

Article Figures & Tables

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    At the start of each block, participants were instructed to make a judgment about similarity or preference. Each trial started with a fixation period of 1500–2000 ms, followed by the stimulus and response arrays. The stimulus array consisted of 3 colour swatches on which participants made their judgment. Then, a dark grey horizontal line appeared to indicate the start of the response period, during which participants would press the left or right button to indicate their decision.

  • Figure 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2

    Mean event-related potential amplitudes at different scalp areas, 900–2000 ms after onset of the stimulus array, shown separately for (A) the control group and (B) the MDD group. Responses during the similarity condition are shown in blue, and responses during the preference condition are shown in red. We observed differences between the conditions at frontal and central areas in the MDD group but not in the control group. Error bars represent the standard error of the mean. *p < 0.05. MDD = major depressive disorder.

  • Figure 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3

    Similarity–preference differences for (A) the MDD group and (B) the control group. The electrodes for which comparisons were done are indicated by black dots in the leftmost topographical maps. These maps show similarity–preference differences over time. The waveforms represent similarity–preference differences for each selected electrode. Significant differences per electrode are shown in black. Periods in which at least 1 difference was found are shaded in grey. Visualizations were created using the EEGVIS toolbox.45 MDD = major depressive disorder.

  • Figure 4
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4

    Differences in the amplitude of sustained responses between preference and similarity conditions were correlated with scores on (A) the BDI and (B) the RRS (MDD group, orange; control group, grey). We observed significant relationships between amplitude differences and scores for participants with MDD but not for controls. BDI = Beck Depression Inventory; MDD = major depressive disorder; RRS = Rumination Response Scale.

  • Figure 5
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5

    (A) Theta band oscillatory power at Cz as a function of condition for the MDD and control groups. Dots represent values from individuals in the similarity (blue) and preference (red) conditions. Group means are indicated by diamonds. Power spectra from which we obtained values are shown for (B) the control group and (C) the MDD group. Insets show a close-up of the theta range indicated by grey shading in the main spectra. *p < 0.05. MDD = major depressive disorder.

Tables

  • Figures
    • View popup
    Table 1

    Beck Depression Inventory and Rumination Response Scale

    Scale*ControlMDDComparison
    Beck Depression Inventory score7.8 ± 7.728.7 ± 14.4t = −6.7, p < 0.001
    Rumination Response Scale score40.4 ± 12.562.8 ± 14t = −6.1, p < 0.001
    • ↵* Values are mean ± standard deviation.

    • View popup
    Table 2

    Behavioural responses in each task condition for control and MDD groups

    Response*SimilarityPreference
    LowHigh
    Accuracy
     Control0.89 ± 0.070.64 ± 0.11—
     MDD0.84 ± 0.150.59 ± 0.16—
    Reaction time, ms
     Control627 ± 107647 ± 100637 ± 102
     MDD646 ± 104664 ± 97655 ± 99
    • MDD = major depressive disorder.

    • ↵* Values are mean ± standard deviation.

PreviousNext
Back to top

In this issue

Journal of Psychiatry and Neuroscience: 46 (5)
J Psychiatry Neurosci
Vol. 46, Issue 5
1 Sep 2021
  • Table of Contents
  • Index by author

Article tools

Respond to this article
Print
Download PDF
Article Alerts
To sign up for email alerts or to access your current email alerts, enter your email address below:
Email Article

Thank you for your interest in spreading the word on JPN.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Depressive rumination is correlated with brain responses during self-related processing
(Your Name) has sent you a message from JPN
(Your Name) thought you would like to see the JPN web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Depressive rumination is correlated with brain responses during self-related processing
Tzu-Yu Hsu, Tzu-Ling Liu, Paul Z. Cheng, Hsin-Chien Lee, Timothy J. Lane, Niall W. Duncan
J Psychiatry Neurosci Sep 2021, 46 (5) E518-E527; DOI: 10.1503/jpn.210052

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
‍ Request Permissions
Share
Depressive rumination is correlated with brain responses during self-related processing
Tzu-Yu Hsu, Tzu-Ling Liu, Paul Z. Cheng, Hsin-Chien Lee, Timothy J. Lane, Niall W. Duncan
J Psychiatry Neurosci Sep 2021, 46 (5) E518-E527; DOI: 10.1503/jpn.210052
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

Similar Articles

Content

  • Current issue
  • Past issues
  • Collections
  • Alerts
  • RSS

Authors & Reviewers

  • Overview for Authors
  • Submit a manuscript
  • Manuscript Submission Checklist

About

  • General Information
  • Staff
  • Editorial Board
  • Contact Us
  • Advertising
  • Reprints
  • Copyright and Permissions
CMAJ Group

Copyright 2023, CMA Impact Inc. or its licensors. All rights reserved. ISSN 1180-4882.

All editorial matter in JPN represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.
To receive any of these resources in an accessible format, please contact us at CMAJ Group, 500-1410 Blair Towers Place, Ottawa ON, K1J 9B9; p: 1-888-855-2555; e: [email protected].

CMA Civility, Accessibility, Privacy

 

Powered by HighWire