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Research Paper
Open Access

Load-dependent inverted U–shaped connectivity of the default mode network in schizophrenia during a working-memory task: evidence from a replication functional MRI study

Feiwen Wang, Chang Xi, Zhening Liu, Mengjie Deng, Wen Zhang, Hengyi Cao, Jie Yang and Lena Palaniyappan
J Psychiatry Neurosci September 27, 2022 47 (5) E341-E350; DOI: https://doi.org/10.1503/jpn.220053
Feiwen Wang
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Chang Xi
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Zhening Liu
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Mengjie Deng
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Wen Zhang
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Hengyi Cao
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Jie Yang
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Lena Palaniyappan
From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan)
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Journal of Psychiatry and Neuroscience: 47 (5)
J Psychiatry Neurosci
Vol. 47, Issue 5
25 Oct 2022
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Load-dependent inverted U–shaped connectivity of the default mode network in schizophrenia during a working-memory task: evidence from a replication functional MRI study
Feiwen Wang, Chang Xi, Zhening Liu, Mengjie Deng, Wen Zhang, Hengyi Cao, Jie Yang, Lena Palaniyappan
J Psychiatry Neurosci Sep 2022, 47 (5) E341-E350; DOI: 10.1503/jpn.220053

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Load-dependent inverted U–shaped connectivity of the default mode network in schizophrenia during a working-memory task: evidence from a replication functional MRI study
Feiwen Wang, Chang Xi, Zhening Liu, Mengjie Deng, Wen Zhang, Hengyi Cao, Jie Yang, Lena Palaniyappan
J Psychiatry Neurosci Sep 2022, 47 (5) E341-E350; DOI: 10.1503/jpn.220053
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