Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a randomized controlled trial

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)

From the University of Basel, Department of Psychiatry (UPK), Basel, Switzerland (Schneider, Doll, Schweinfurth, Kettelhack, Schaub, Yamanbaeva, Varghese, Mählmann, Brand, Eckert, Borgwardt, Lang, Schmidt); the Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland (Varghese, Eckert); the Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran (Brand); the Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, Switzerland (Brand); the School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Brand); the Department of Research, St. Clara Hospital, Basel, Switzerland ([CE; authors were not indicated for this affiliation]}; the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Borgwardt)