Figure 5 Effects of intracranial self-stimulation (ICSS) of the medial forebrain bundle on hippocampal neurodegeneration in rats treated with streptozotocin (STZ). (A) Representative photomicrographs of Nissl-stained sections of CA1 (a, b, c), dentate gyrus (DG) (d, e, f), and dorsal tenia tecta (DTT) (g, h, i) regions for control (a, d, and g), STZ (b, e, and h), and STZ+ICSS groups (c, f, and i) (scale bar = 100 μm). (B) Neuronal density in the CA1 and DG regions, for the control, STZ, and STZ+ICSS groups. (C) Percent neurodegeneration in the DTT region for the control, STZ, and STZ+ICSS groups. Data in Figure 5B and 5C represent mean ± standard error of the mean; *p < 0.05 relative to control.