Research Paper
MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
Armaz Aschrafi, Jan M. Verheijen, Peter M. Gordebeke, Nikkie F. Olde Loohuis, Kelly Menting, Amanda Jager, Miklos Palkovits, Bram Geenen, Aron Kos, Gerard J.M. Martens, Jeffrey C. Glennon, Barry B. Kaplan, Balázs Gaszner and Tamas Kozicz
J Psychiatry Neurosci September 01, 2016 41 (5) 342-353; DOI: https://doi.org/10.1503/jpn.150154
Armaz Aschrafi
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Jan M. Verheijen
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Peter M. Gordebeke
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Nikkie F. Olde Loohuis
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Kelly Menting
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Amanda Jager
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Miklos Palkovits
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Bram Geenen
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Aron Kos
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Gerard J.M. Martens
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Jeffrey C. Glennon
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Barry B. Kaplan
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Balázs Gaszner
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)
Tamas Kozicz
From the Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands (Aschrafi, Verheijen, Gordebeke, Menting, Geenan, Kozicz); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands (Loohuis, Jager, Kos, Glennon); the Department of Anatomy, Semmelweis University Budapest, Budapest, Hungary (Palkovits); the Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands (Martens); the Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Aschrafi, Kaplan); the Department of Anatomy, Pécs University, Medical Faculty, Pécs, Hungary (Gaszner); the Hayward Genetics Center, Department of Pediatrics, Tulane University, New Orleans, LA (Kozicz); and the Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium (Verheijen)

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MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
Armaz Aschrafi, Jan M. Verheijen, Peter M. Gordebeke, Nikkie F. Olde Loohuis, Kelly Menting, Amanda Jager, Miklos Palkovits, Bram Geenen, Aron Kos, Gerard J.M. Martens, Jeffrey C. Glennon, Barry B. Kaplan, Balázs Gaszner, Tamas Kozicz
J Psychiatry Neurosci Sep 2016, 41 (5) 342-353; DOI: 10.1503/jpn.150154
MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
Armaz Aschrafi, Jan M. Verheijen, Peter M. Gordebeke, Nikkie F. Olde Loohuis, Kelly Menting, Amanda Jager, Miklos Palkovits, Bram Geenen, Aron Kos, Gerard J.M. Martens, Jeffrey C. Glennon, Barry B. Kaplan, Balázs Gaszner, Tamas Kozicz
J Psychiatry Neurosci Sep 2016, 41 (5) 342-353; DOI: 10.1503/jpn.150154
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