Article Figures & Tables
Figures
- Fig. 1
Group comparison of brain activation during the general no-go task. Differences in group activation between healthy controls and patients with bulimia nervosa with a high frequency of binge eating (controls > high-BN) during the contrast no-go_circle–go_square. The significance threshold was set at p < 0.05, cluster-level uncorrected. The SPM t-map was rendered on a T1-weighted template image supplied with mricron (Colin brain). The colour scale represents the t-scores.
- Fig. 2
Brain activation extracted from the significant clusters of the whole brain analysis (regions of interest) for the general and food-specific no-go task in healthy controls and bulimia nervosa subgroups. Bar charts depicting percent signal change from the significant clusters (right postcentral gyrus, right caudate nucleus) for the controls and patients during the no-go_circle–go_square (light colour) and the no-go_food–go_nonfood (dark colour) contrasts. Error bars depict standard errors of the mean (SEM). High-BN = patients with bulimia nervosa with a high frequency of binge eating; low-BN = patients with bulimia nervosa with a low frequency of binge eating.
Tables
Group; mean ± SD or % Characteristic Control, n = 29 Bulimia, n = 28 t55 p value BDI-II total 3.59 ± 3.13 25.63 ± 12.43 9.248 < 0.001 DEBQ Restrained eating 11.79 ± 8.13 28.89 ± 7.76 8.119 < 0.001 Emotional eating 7.28 ± 4.74 28.45 ± 8.05 12.148 < 0.001 External eating 18.38 ± 6.68 25.14 ± 7.31 3.649 < 0.001 BIS-11 Total score 58.48 ± 6.44 61.81 ± 8.96 1.606 0.11 Attentional impulsiveness 14.52 ± 2.08 17.89 ± 3.71 4.229 < 0.001 Motor impulsiveness 21.28 ± 3.02 19.00 ± 3.68 −2.537 0.014 Nonplanning impulsiveness 22.69 ± 3.53 24.93 ± 5.12 1.915 0.06 Objective binge eating episodes/wk — 3.71 ± 2.53 — — Purging-type (self-induced vomiting, laxative misuse, diuretics) — 85.71 — — Disorder duration, yr — 10.19 ± 11.35 — — Antidepressants — 25.00 — — Current psychotherapy — 53.57 — — Subclinical bulimia* — 3.57 — — BDI = Beck Depression Inventory-II; BIS-11 = Barratt Impulsiveness Scale; DEBQ = Dutch Eating Behaviour Questionnaire; SD = standard deviation.
↵* Patient with subclinical bulimia nervosa with no binge eating episodes during the 28 d before participation.
Group; mean ± SD Measure Control, n = 29 Bulimia, n = 28 t55 p value Correct% Go_square 98.73 ± 3.25 99.04 ± 1.94 0.426 0.67 No-go_circle 83.46 ± 10.41 77.12 ± 12.32 −2.101 0.040 Go_nonfood 98.67 ± 3.68 98.47 ± 3.41 −0.214 0.83 No-go_food 81.25 ± 9.21 78.91 ± 8.58 −0.993 0.33 RT, ms Go_square 357.88 ± 38.06 358.86 ± 41.62 0.093 0.93 No-go_circle 322.28 ± 42.70 326.02 ± 49.58 0.306 0.76 Go_nonfood 415.28 ± 38.83 412.80 ± 40.67 −0.236 0.81 No-go_food 377.32 ± 48.72 389.76 ± 57.98 0.878 0.38 RT = reaction time; SD = standard deviation.
- Table 3
Whole brain results of the comparison between healthy controls (n = 29) and patients with bulimia nervosa with severe symptoms (n = 14) for the general no-go task
MNI coordinates Region Laterality t value x y z BA Cluster size Controls > bulimia nervosa Postcentral gyrus (parietal lobe)* R 5.05 33 −25 38 3 141 Precentral gyrus (frontal lobe)* R 4.04 15 −28 70 4 Postcentral gyrus (parietal lobe)* R 3.99 33 −28 66 4/6 Caudate nucleus† R 4.55 18 11 18 36 Putamen† R 4.01 27 17 10 BA = Brodmann area; FWE = family-wise error; MNI = Montreal Neurological Institute; R = right.
↵* Results significant at p < 0.05 cluster-level, FWE-corrected; cluster-defining threshold p < 0.001, uncorrected. Cluster size k > 10 voxels.
↵† Results significant at p < 0.05 cluster-level uncorrected, cluster-defining threshold p < 0.001 uncorrected. Cluster size k > 10 voxels.
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