Research Paper
Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Sarah M. Clark, Ana Pocivavsek, James D. Nicholson, Francesca M. Notarangelo, Patricia Langenberg, Robert P. McMahon, Joel E. Kleinman, Thomas M. Hyde, John Stiller, Teodor T. Postolache, Robert Schwarcz and Leonardo H. Tonelli
J Psychiatry Neurosci November 01, 2016 41 (6) 386-394; DOI: https://doi.org/10.1503/jpn.150226
Sarah M. Clark
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDAna Pocivavsek
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDJames D. Nicholson
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDFrancesca M. Notarangelo
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDPatricia Langenberg
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDRobert P. McMahon
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDJoel E. Kleinman
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
MD, PhDThomas M. Hyde
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
MD, PhDJohn Stiller
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
MDTeodor T. Postolache
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
MDRobert Schwarcz
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhDLeonardo H. Tonelli
From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache)
PhD
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Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Sarah M. Clark, Ana Pocivavsek, James D. Nicholson, Francesca M. Notarangelo, Patricia Langenberg, Robert P. McMahon, Joel E. Kleinman, Thomas M. Hyde, John Stiller, Teodor T. Postolache, Robert Schwarcz, Leonardo H. Tonelli
J Psychiatry Neurosci Nov 2016, 41 (6) 386-394; DOI: 10.1503/jpn.150226
Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Sarah M. Clark, Ana Pocivavsek, James D. Nicholson, Francesca M. Notarangelo, Patricia Langenberg, Robert P. McMahon, Joel E. Kleinman, Thomas M. Hyde, John Stiller, Teodor T. Postolache, Robert Schwarcz, Leonardo H. Tonelli
J Psychiatry Neurosci Nov 2016, 41 (6) 386-394; DOI: 10.1503/jpn.150226