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Research Paper

Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder

Huimeng Lei, Juan Lai, Xiaohong Sun, Qunyuan Xu and Guoping Feng
J Psychiatry Neurosci March 01, 2019 44 (2) 120-131; DOI: https://doi.org/10.1503/jpn.180032
Huimeng Lei
From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
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Juan Lai
From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
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Xiaohong Sun
From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
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Qunyuan Xu
From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
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Guoping Feng
From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
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Article Information

vol. 44 no. 2 120-131
DOI 
https://doi.org/10.1503/jpn.180032
PubMed 
30403026
History 
  • Received February 28, 2018
  • Revision received May 18, 2018
  • Accepted June 27, 2018
  • Published online March 1, 2019.
Copyright & Usage 
© 2019 Joule Inc. or its licensors

Author Information

  1. Huimeng Lei, PhD,
  2. Juan Lai, MS,
  3. Xiaohong Sun, BS,
  4. Qunyuan Xu, MD, PhD,
  5. Guoping Feng, MD, PhD
  1. From the Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Centre of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, China (Lei, Lai, Sun, Xu); the McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts (Feng); and the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts (Feng).
  1. Correspondence to: H. Lei, Department of Neurobiology, Capital Medical University, You An Men Wai, Xi Tou Tiao, No. 10 Beijing, Beijing 1000069, China; leihm{at}ccmu.edu.cn; G. Feng, McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139; fengg{at}mit.edu.
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Journal of Psychiatry and Neuroscience: 44 (2)
J Psychiatry Neurosci
Vol. 44, Issue 2
1 Mar 2019
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Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder
Huimeng Lei, Juan Lai, Xiaohong Sun, Qunyuan Xu, Guoping Feng
J Psychiatry Neurosci Mar 2019, 44 (2) 120-131; DOI: 10.1503/jpn.180032

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Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder
Huimeng Lei, Juan Lai, Xiaohong Sun, Qunyuan Xu, Guoping Feng
J Psychiatry Neurosci Mar 2019, 44 (2) 120-131; DOI: 10.1503/jpn.180032
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