Research Paper
Open Access
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh and Isabelle Boileau
J Psychiatry Neurosci March 01, 2021 46 (2) E238-E246; DOI: https://doi.org/10.1503/jpn.200010
Duncan G.J. Green
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
HBScJinhee Kim
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDStephen J. Kish
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDRachel F. Tyndale
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDMatthew N. Hill
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDAntonio P. Strafella
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MD, PhDJunchao Tong
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDTina McCluskey
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MScDuncan J. Westwood
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
HBScSylvain Houle
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MD, PhDNancy J. Lobaugh
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDIsabelle Boileau
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
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Article Information
vol. 46 no. 2 E238-E246
PubMed
History
- Received January 22, 2020
- Revision received July 3, 2020
- Accepted September 29, 2020
- Published online March 1, 2021.
Copyright & Usage
© 2021 Joule Inc. or its licensors This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
Author Information
- Duncan G.J. Green, HBSc*,
- Jinhee Kim, PhD*,
- Stephen J. Kish, PhD,
- Rachel F. Tyndale, PhD,
- Matthew N. Hill, PhD,
- Antonio P. Strafella, MD, PhD,
- Junchao Tong, PhD,
- Tina McCluskey, MSc,
- Duncan J. Westwood, HBSc,
- Sylvain Houle, MD, PhD,
- Nancy J. Lobaugh, PhD,
- Isabelle Boileau, PhD
- From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
- Correspondence to: I. Boileau, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8; isabelle.boileau{at}camh.ca
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Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
J Psychiatry Neurosci Mar 2021, 46 (2) E238-E246; DOI: 10.1503/jpn.200010
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
J Psychiatry Neurosci Mar 2021, 46 (2) E238-E246; DOI: 10.1503/jpn.200010
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