Research Paper
Open Access
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh and Isabelle Boileau
J Psychiatry Neurosci March 01, 2021 46 (2) E238-E246; DOI: https://doi.org/10.1503/jpn.200010
Duncan G.J. Green
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
HBScJinhee Kim
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDStephen J. Kish
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDRachel F. Tyndale
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDMatthew N. Hill
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDAntonio P. Strafella
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MD, PhDJunchao Tong
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDTina McCluskey
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MScDuncan J. Westwood
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
HBScSylvain Houle
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
MD, PhDNancy J. Lobaugh
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
PhDIsabelle Boileau
From the Addiction Imaging Research Group, Toronto, Ont., Canada (Green, Westwood, Boileau); the Human Brain Lab, Toronto, Ont., Canada (Kish, Tong, McCluskey); the Campbell Family Mental Health Research Institute, Ont., Canada (Kim, Tyndale, Strafella, Houle, Lobaugh, Boileau); the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Kim, Kish, Strafella, Tong, McCluskey, Houle, Lobaugh); the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale, Strafella, Houle, Boileau); the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada (Kish, Tyndale); the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada (Green, Kish, Houle, Lobaugh, Boileau); the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada (Hill); the Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ont., Canada (Strafella); and the Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Lobaugh)
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Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
J Psychiatry Neurosci Mar 2021, 46 (2) E238-E246; DOI: 10.1503/jpn.200010
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
J Psychiatry Neurosci Mar 2021, 46 (2) E238-E246; DOI: 10.1503/jpn.200010
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