5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression

Louisa J. Steinberg; Mark D. Underwood; Mihran J. Bakalian; Suham A. Kassir; J. John Mann; Victoria Arango

doi:10.1503/jpn.180190

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Fig. 1
[³H]Ketanserin binding across Brodmann area (BA) 4, BA 9, BA 22, and BA 41/42 in healthy controls (HC) and individuals with a history of major depressive episodes (MDE). [³H]Ketanserin binding was 33% lower in BA41/42 of the MDE compared with the control group (MDE mean 20.59 ± 6.5 fmol/mg, HC mean 30.78 ± 7.8 fmol/mg; t = −3.05, p = 0.0069). There were no significant differences in BA 4 (MDE mean 24.81 ± 8.35 fmol/mg, HC mean 22.32 ± 6.84 fmol/mg), BA 9 (MDE mean 34.44 ± 12.64 fmol/mg, HC mean 30.4 ± 9.57 fmol/mg), and BA 22 (MDE mean 25.86 ± 10.65 fmol/mg, HC mean 24.76 ± 8.75 fmol/mg).
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Fig. 2
[³H]8-OH-DPAT binding across Brodmann area (BA) 4, BA 9, BA 22, and BA 41/42 in healthy controls (HC) and individuals with a history of major depressive episodes (MDE). [³H]8-OH-DPAT binding was 14% higher in BA 9 of the MDE group compared with the control group (MDE mean 16.07 ± 3.92 fmol/mg, HC mean 13.98 + 3.99 fmol/mg, t = 2.05, p = 0.045). However, after accounting for the effects of age and sex, this finding became a trend-level observation (t = 1.79, p = 0.079). There was no significant difference between the MDE group and the control group in BA 4 (MDE mean 12.17 ± 5.45 fmol/mg, HC mean 10.56 ± 4.15 fmol/mg), BA 22 (MDE mean 16.13 ± 6.44 fmol/mg, HC 14.07 ± 5.38 fmol/mg), and BA 41/42 (MDE mean 12.84 ± 3.42 fmol/mg, HC mean 9.47 ± 1.94 fmol/mg).
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Fig. 3
[³H]Cyanoimipramine binding across Brodmann area (BA) 4, BA 9, BA 22, and BA 41/42 in healthy controls (HC) and individuals with a history of major depressive episodes (MDE). [³H]Cyanoimipramine binding was 21% lower in BA 9 in the MDE group compared with the control group in sulcus data (MDE mean 5.65 ± 2.4 fmol/mg, HC mean 7.09 ± 3.14 fmol/mg, t = −2.04, p = 0.045). There was no significant difference between the MDE group and the control group in BA 4 (MDE mean 8.04 ± 6.93 fmol/mg, HC mean 6.61 ± 3.4 fmol/mg), BA 22 (MDE mean 6.89 ± 4.53 fmol/mg, HC mean 7.45 ± 4.25 fmol/mg), and BA 41/42 (MDE mean 8.26 ± 5.04 fmol/mg, HC mean 5.05 ± 1.69 fmol/mg).

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Table 1

Demographic and clinical characteristics of participants in the study

Characteristic	Group, no. (%)^*			p value

	Control (n = 40)	MDE (n = 36)	Whole sample (n = 76)
Age, yr, mean ± SD	48 ± 18.0	47 ± 21.3	48 ± 19.6	0.97
Female sex	9 (22.5)	11 (30.5)	20 (26.3)	0.27
Suicide	—	34 (94.4)	34 (44.7)
Bipolar disorder	—	4 (11.1)	4 (5.2)
AUD	—	12 (33.3)	12 (15.8)
Childhood adversity	10 (25)	10 (27.8)	20 (26.3)	0.74
Race/ethnicity				0.51
Asian	1 (2.5)	1 (2.7)	2 (2.6)
African American	7 (17.5)	2 (5.5)	9 (11.8)
White	28 (70)	27 (75)	55 (72.4)
Hispanic	6 (15)	5 (13.8)	11 (14.5)